Amphotericin B Deoxycholate - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

0.3-1.5mg/kg IV daily, infused over several hours.

Discuss dosing as well as premedication with pharmacy.

0.4-1mg/kg IV q24h, infused over several hours.

Discuss dosing as well as premedication with pharmacy.