C difficile risk
Oral Bioavailability


CrCl >50 mL/minCrCl 10-50 mL/minCrCl <10 mL/min2000mg IV Q4-6h2000mg IV Q6-12h2000mg IV Q12-24h

1000-2000mg IV Q12-24h (doses given on HD days should be given after HD)

Load 2000mg IV, then 1000-2000mg IV Q6-12h

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

PreparationDosingAmpicillin 4g in 500mL NS (8 mg/mL)12 g/24hr (500 mg/hr)

Expiration 8 hoursRoom temperature

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Increased risk of rash with allopurinol.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic