Spectrum: Clinical Decision Support for Infectious Disease, for Prisma Health-Midlands
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Antimicrobials Antimicrobials

Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A
Cost
$$

Spectrum Of Activity

Spectrum Of Activity

Antibiogram Data

Dosing

Renal

CrCl >50 mL/minCrCl 10-50 mL/minCrCl <10 mL/min2000mg IV Q4-6h2000mg IV Q6-12h2000mg IV Q12-24h

1000-2000mg IV Q12-24h (doses given on HD days should be given after HD)

Load 2000mg IV, then 1000-2000mg IV Q6-12h

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

Continuous Infusion

PreparationDosingAmpicillin 4g in 500mL NS (8 mg/mL)12 g/24hr (500 mg/hr)

Expiration 8 hoursRoom temperature

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Increased risk of rash with allopurinol.

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic