CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min1000-2000mg IV Q8h500-1000mg IV Q8h500mg IV Q12h
Load 500-2000mg IV, then 125-500mg Q8-12h (doses given on HD days should be given after HD)
Load 2000mg IV, then 1000-2000mg IV Q8-12h
2g IV q8h for severe infections
Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.
Nebulized form used in cystic fibrosis patients.
Empiric therapy for febrile neutropenia.
Monitor liver enzymes
Elevated liver enzymes
Cytopenias
Eosinophilia
Phlebitis at injection site
Rash/allergy
CNS toxicity
No significant interactions.
Antimicrobial class: Monobactam
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic