Aztreonam

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$$$$$

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min1000-2000mg IV Q8h500-1000mg IV Q8h500mg IV Q12h

Load 500-2000mg IV, then 125-500mg Q8-12h (doses given on HD days should be given after HD)

Load 2000mg IV, then 1000-2000mg IV Q8-12h

2g IV q8h for severe infections

General Information

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Monitor liver enzymes

  • Elevated liver enzymes

  • Cytopenias

  • Eosinophilia

  • Phlebitis at injection site

  • Rash/allergy

  • CNS toxicity

No significant interactions.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic