Aztreonam - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl ≥30 mL/min

1000-2000mg IV Q8h

CrCl 10-29 mL/min

500-1000mg IV Q8h

CrCl <10 mL/min

500mg IV Q12h

Load 500-2000mg IV, then 125-500mg Q8-12h (doses given on HD days should be given after HD)

Load 2000mg IV, then 1000-2000mg IV Q8-12h