CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min2g IV Q8h1-2g IV Q8-12h1-2g IV Q24h
If given after HDIf given with HD1g IV Q24h2g IV (Mon/Tues)
2g IV (Wed/thurs)
3g IV (Fri/Sat)
2g IV Q12h
2g IV q8h (max 6 gm/day)
Skin and soft tissue infection (e.g. cellulitis).
Susceptible Staphylococcal, Streptococcal and gram negative infections.
Allergy (immediate or delayed).
Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.
Probenecid - prolonged half-life.
Drug interaction has been used therapeutically to give once daily cefazolin.
Not recommended unless no other alternatives.
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic