Cefazolin

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$$

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min2g IV Q8h1-2g IV Q8-12h1-2g IV Q24h

If given after HDIf given with HD1g IV Q24h2g IV (Mon/Tues)
2g IV (Wed/thurs)
3g IV (Fri/Sat)

2g IV Q12h

2g IV q8h (max 6 gm/day)

General Information

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Probenecid - prolonged half-life.

Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic