Cefepime

C difficile risk
High
Oral Bioavailability
N/A
Cost
$$

Dosing

CrCl >50 mL/minCrCl 30-50 mL/minCrCl 10-29 mL/minCrCl <10 mL/min2g IV/IM Q8-12h2g IV/IM Q12h1g IV/IM Q24h500mg IV/IM Q24h

If given after HDIf given with HD1g IV Q24h2g IV (Mon/Tues)
2g IV (Wed/Thurs)
3g IV (Fri/Sat)

Load 2g IV/IM, then 2g IV/IM Q12h

2g IV q8-12h

General Information

Antimicrobial Stewardship will review therapies greater than 72 hours.

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • Non-convulsive status epilepticus

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate