CrCl >50 mL/minCrCl 30-50 mL/minCrCl 10-29 mL/minCrCl <10 mL/min2000mg IV Q8-12h1000mg IV Q12h1000mg IV Q24h500mg IV Q24h
If given after HDIf given with HD1000mg IV Q24h2000mg IV (Mon/Tues)
2000mg IV (Wed/Thurs)
3000mg IV (Fri/Sat)
2000mg IV Q24h
1-2g IV q8h
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic