Ceftazidime

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
$$

Dosing

CrCl >50 mL/minCrCl 30-50 mL/minCrCl 10-29 mL/minCrCl <10 mL/min2000mg IV Q8-12h1000mg IV Q12h1000mg IV Q24h500mg IV Q24h

If given after HDIf given with HD1000mg IV Q24h2000mg IV (Mon/Tues)
2000mg IV (Wed/Thurs)
3000mg IV (Fri/Sat)

2000mg IV Q24h

1-2g IV q8h

General Information

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic