Ceftriaxone

C difficile risk
High
Oral Bioavailability
N/A
Cost
$

Dosing

1000-2000mg IV/IM Q24h

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

General Information

Empiric therapy of:

  • Bacterial meningitis

  • Nosocomial gram negative infections (except Pseudomonas)

  • Spontaneous bacterial peritonitis

  • Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic