Cefuroxime

C difficile risk
High
Oral Bioavailability
Moderate
Cost
$

Spectrum Of Activity

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min250-500mg PO Q12h250-500mg PO Q24h250-500mg PO Q48h

250mg PO Q24h

750-1500mg IV q8h

500mg PO q12h

General Information

  • Community acquired pneumonia with a macrolide

  • Intraabdominal infection

  • Epiglottitis

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

No significant interactions.

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic