Cephalexin

C difficile risk
Medium
Oral Bioavailability
Moderate
Cost
¢

Spectrum Of Activity

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min250-1000mg PO Q6h250mg PO Q8-12h250-500mg PO Q24-48h

250-500mg PO Q24-48h (doses given on HD days should be given after HD)

250-500mg Q24-48h

500-1000mg PO QID

General Information

  • Uncomplicated skin and soft tissue infection

  • MSSA infections

  • Allergy/rash (immediate or delayed)

  • Positive Coombs

  • Cytopenias

  • Eosinophilia

  • Hepatic & renal laboratory abnormalities

Increases metformin levels

Antimicrobial class: First Generation Cephalosporin.

Pregnancy category: B

Biliary penetration: Moderate

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic