Cephalexin - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl ≥30 mL/min

250-1000mg PO Q6h

CrCl 10-29 mL/min

250mg PO Q8-12h

CrCl <10 mL/min

250-500mg PO Q24-48h

250-500mg PO Q24-48h (doses given on HD days should be given after HD)

250-500mg Q24-48h