Ciprofloxacin - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

250-750mg PO Q12h, or 400mg IV Q8-12h

CrCl ≤50 mL/min

250-500mg IM Q12, or 500mg ER Q12h, or 200-400mg PO Q18-24h

500mg PO/ 400mg IV Q24h (doses given on HD days should be given after HD)

200-400mg IV Q12h