150-450mg PO Q6-8h or 600-900mg IV Q8h
Usual indications 300-450mg IV q8h
Necrotizing SSTI or toxic shock syndrome 900mg IV q8h
Oral Dosing 300-450mg PO q6h
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Monitor for diarrhea.
Muscle relaxants, e.g., atracurium, baclofen, diazepam.
St. Johns Wort
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor