Clindamycin

C difficile risk
High
Oral Bioavailability
Excellent
Cost
IV:$$$ PO:$$

Dosing

150-450mg PO Q6-8h or 600-900mg IV Q8h

Usual indications 300-450mg IV q8h

Necrotizing SSTI or toxic shock syndrome 900mg IV q8h

Oral Dosing 300-450mg PO q6h

General Information

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

None specific.

Monitor for diarrhea.

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor