Antimicrobials
Daptomycin

Daptomycin

Restricted

Low
N/A
$

Spectrum of Activity

Dosing

General Information

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. S. aureus with high vancomycin MIC (2 mcg/ml)
  2. Documented VRE from a non-urine source
  3. Documented vancomycin allergy - NOT Red Man's
  4. Vancomycin failure of therapy (≥ 5 days)

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection

Creatine kinase weekly

  • GI side effects common
  • Rash
  • Phlebitis
  • Increased INR
  • Myopathy including rhabdomyolysis
  • Statins and fibrates - Increased myopathy
  • Monitor creatine kinase or hold while on daptomycin therapy
  • Higher doses used for endovascular infection
  • Recommend Infectious Disease Consult
  • Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection

Antimicrobial class: Cyclic Lipopeptide

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic