CrCl ≥30 mL/minCrCl <30 mL/min6-10 mg/kg IV Q24h4-6 mg/kg IV Q48h
4-6 mg/kg IV Q48h (doses given on HD days should be given after HD)
8 mg/kg IV Q48h
Unknown for severe hepatic dysfunction
Endocarditis or bloodstream infection 6-10mg/kg IV daily
Non-bloodstream infections 4mg/kg IV daily
Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection
Creatine kinase weekly
GI side effects common
Myopathy including rhabdomyolysis
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
Higher doses used for endovascular infection.
Recommend Infectious Disease Consult.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide.
Pregnancy category: B
Average serum half life: 9 hours
CSF penetration: Poor
Lung penetration: Poor
Urine penetration: Therapeutic