Doxycycline

C difficile risk
Low
Oral Bioavailability
Excellent
Cost
IV:$$ PO:ยข

Dosing

100mg PO/IV Q12h

100mg PO/IV BID

General Information

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • Methicillin resistant staphylococcus aureus infections

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic