Antimicrobials
Ertapenem

Ertapenem

Restricted

High
N/A
$$$$

Dosing

General Information

Approved Criteria:

  1. Documented infection due to ESBL- NOT cystitis
  2. Rapid diagnostic confirmed bacteremia with E. coli OR Klebsiella PLUS High Risk (ESBL Risk Score ≥2) AND Critically Ill (Pitt ≥4)
  3. Ordered by Infectious Disease/Antimicrobial Stewardship Provider
  4. NOT Approved for Preoperative Use at Prisma Health

NOT APPROVED for Preoperative Use at Prisma Health

  • Targeted therapy of ESBL infections and other resistant gram negative infections
  • Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity
  • Immediate and delayed-type allergy
  • GI disturbance
  • Cytopenias, eosinophilia, positive Coombs
  • Liver enzyme abnormalities
  • Seizure risk lower than other carbapenems

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic