Fosfomycin

C difficile risk
Low
Oral Bioavailability
Moderate
Cost
$$$

Spectrum Of Activity

Dosing

3000mg PO Q3 days

Female, Uncomplicated UTI 3g PO once

Complicated or male UTI 3g PO q2-3days x 3 doses

General Information

Urinary Tract Infection, especially involving ESBL producing organisms

Offlabel - Prostatitis

  • GI upset, especially diarrhea

  • Headache

  • Eosinophilia, neutropenia

  • Hypokalemia

No significant interactions

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic