Levofloxacin - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl ≥30 mL/min

500mg PO/IV Q24 or 750mg PO/IV Q24h

CrCl 10-29 mL/min

500mg PO/IV, then 250mg PO/IV Q24-48h

CrCl <10 mL/min

Usual initial dose, then 250-500mg PO/IV Q48h

Usual initial dose, then 250-500mg PO/IV Q48h

Load 500-750mg PO/IV, then 250-750mg PO/IV Q24h