Meropenem

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
$$$

Dosing

CrCl >50 mL/minCrCl 30-50 mL/minCrCl 10-29 mL/minCrCl <10 mL/min1000mg IV Q8h1000mg IV Q12h500mg IV Q12h500mg IV Q24h

500mg IV Q24h (doses given on HD days should be given after HD)

Load 1000mg IV, then 500mg IV Q8h or 1000mg IV Q12h

Standard Dose 500mg IV q6h or 1g IV q8h

Meningitis 2g IV q8h

General Information

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented infection with P.aeruginosa
  2. Penicillin AND cephalosporin allergies
  3. High suspicion for ESBLs or P.aeruginosa
  4. Peds ONLY - Hemodynamically unstable
  5. Peds ONLY - Fever/neutropenia & typhlitis
  6. Peds ONLY - Suspected NEC - severe

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic