Spectrum: Clinical Decision Support for Infectious Disease, for Prisma Health-Midlands
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Antimicrobials Antimicrobials

Meropenem

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
$$$

Spectrum Of Activity

Spectrum Of Activity

Antibiogram Data

Dosing

Renal

CrCl >50 mL/minCrCl 30-50 mL/minCrCl 10-29 mL/minCrCl <10 mL/min1000mg IV Q8h1000mg IV Q12h500mg IV Q12h500mg IV Q24h

500mg IV Q24h (doses given on HD days should be given after HD)

Load 1000mg IV, then 500mg IV Q8h or 1000mg IV Q12h

Adult

Standard Dose 500mg IV q6h or 1g IV q8h

Meningitis 2g IV q8h

General Information

Appropriate Use

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented infection with P.aeruginosa
  2. Penicillin AND cephalosporin allergies
  3. High suspicion for ESBLs or P.aeruginosa
  4. Peds ONLY - Hemodynamically unstable
  5. Peds ONLY - Fever/neutropenia & typhlitis
  6. Peds ONLY - Suspected NEC - severe

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

Adverse Effects

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic