CrCl >30 mL/minCrCl ≤30 mL/min MacroBID (nirofurantoin monohydrate) 100mg PO Q12hDo not use
Do not use
Cystitis Macrobid 100mg PO BID
Uncomplicated cystitis in females with normal renal function
Interstitial pneumonitis and fibrosis especially with prolonged use.
Antacids decrease absorption
Think of this drug as a urinary antiseptic.
Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.
Antimicrobial class: Nitrofuran
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: None
CSF penetration: None
Lung penetration: None
Urine penetration: Therapeutic