C difficile risk
Oral Bioavailability


CrCl >30 mL/minCrCl ≤30 mL/min MacroBID (nirofurantoin monohydrate) 100mg PO Q12hDo not use

Do not use

Do not use

Cystitis Macrobid 100mg PO BID

General Information

Uncomplicated cystitis in females with normal renal function

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Antacids decrease absorption

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic