CrCl > 60ml/minCrCl >30 to 60ml/minCrCl >10 to 30ml/minNo dosage adjusmtent30mg PO BID30mg PO Daily
30mg PO load then 30mg PO after each HD session for 5 day period
30mg PO q24h
Immunocompromised or critically ill 75mg PO BID x 5 days or longer
Prophylaxis 75mg PO daily
Treatment and prophylaxis of influenza
GI upset common
Rare - Stevens Johnson
Neuropsychiatric side effects reported
No significant interactions
Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.
Antimicrobial class: Antiviral - Neuraminidase inhibitor
Pregnancy category: C
Average serum half life: 2 hours
Lung penetration: Therapeutic