Oseltamivir

C difficile risk
None
Oral Bioavailability
Excellent

Spectrum Of Activity

Dosing

CrCl > 60ml/minCrCl >30 to 60ml/minCrCl >10 to 30ml/minNo dosage adjusmtent30mg PO BID30mg PO Daily

30mg PO load then 30mg PO after each HD session for 5 day period

30mg PO q24h

Immunocompromised or critically ill 75mg PO BID x 5 days or longer

Prophylaxis 75mg PO daily

General Information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant interactions

Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic