Oseltamivir - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl > 60ml/min

No dosage adjusmtent

CrCl >30 to 60ml/min

30mg PO BID

CrCl >10 to 30ml/min

30mg PO Daily

30mg PO load then 30mg PO after each HD session for 5 day period

30mg PO q24h