Penicillin G

C difficile risk
Oral Bioavailability


2-4 MU IV Q4h

0.5-1 MU IV Q4-6h, or 1-2 MU IV Q8-12h (doses given on HD days should be given after HD)

Load 4 MU IV, then 2-4 MU IV Q4-6h

12-24 million units/day IV in 6 divided doses

PreparationDosingPenicillin G Potassium 12MU in 500mL NS (24,000 units/mL)24 MU/24hr (1MU/hr)

Expiration 24 hoursRoom temperature

General Information

Therapy of Streptococcal and other documented susceptible infections.

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic