Piperacillin/Tazobactam

C difficile risk
High
Oral Bioavailability
N/A
Cost
$$$

Dosing

CrCl >50 mL/minCrCl 30-50 mL/minCrCl <29 mL/min3.375-4.5g IV Q6h2.25g IV Q6h or 3.375g IV Q8h2.25g IV Q6-8h

2.25g IV Q8-12h (doses given on HD days should be given after HD)

2.25-3.375g IV Q6-8h

3.375-4.5g IV q6h

General Information

Antimicrobial Stewardship will review therapies greater than 72 hours.

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  • Pneumonia

  • Intra-abdominal/hepatobiliary

  • UTI

  • Polymicrobial skin and soft tissue infection

  • Febrile neutropenia

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Incr. levels of methotrexate

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic