Piperacillin/Tazobactam - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

3.375-4.5g IV Q6h

CrCl 30-50 mL/min

2.25g IV Q6h or 3.375g IV Q8h

CrCl <29 mL/min

2.25g IV Q6-8h

2.25g IV Q8-12h (doses given on HD days should be given after HD)

2.25-3.375g IV Q6-8h