Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.
Approved Indications:
Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.
Target trough 15-20mcg/mL for most serious infections, 20-25mcg/mL for meningitis
If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval
If trough >20, increase dosing interval or decrease dose
Aminoglycosides may potentiate nephrotoxicity.
May enhance neuromuscular blockade of NM blocking agents.
Careful with concomitant nephrotoxins.
-Treatment of serious infections due to β-lactam resistant Gram positive microorganisms documented by cultures
Antimicrobial class: Glycopeptide
Pregnancy category: C
Average serum half life: 8 hours
Biliary penetration: Moderate
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic