Skin and Soft Tissue Infection (SSTI)
All dosages assume normal renal and hepatic function
Blood cultures should be collected to assist in identification of a causative pathogen
Supportive measure such as limb elevation are important for rapid resolution of swelling
Streamline definitive therapy based on antimicrobial susceptibility testing results
Patients with penicillin allergy should not receive nafcillin or piperacillin/tazobactam
Non-specific rashes, GI intolerances, etc.
Cross reactivity with 3rd and 4th generation cephalosporins is low (<3%)
The benefit form beta-lactam antibiotics may outweigh the potential risk
Recommendations are modified from the Infectious Disease Society of America (IDSA) 2014 SSTI Management Guidelines
1) Stevens DL, Bisno AL, Chambers HF, et al. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clin Infect Dis 2014;59:e10-52.
2) Pichichero ME. Cephalosporins can be prescribed safely for penicillin-allergic patients. J Fam Pract 2006;55:106-112