Non-Purulent Cellulitis

Empiric Antimicrobial Therapy

Use 2G if weight >80kg

OR

Use 2G if weight >80kg

OR

Use 2G if weight >80kg

OR

Alternative (including for patients with severe penicillin allergy i.e. anaphylaxis, angioedema, hives, etc.)

De-escalate To PO Antibiotics

De-escalation should occur when fever subsides and signs and symptoms of skin infection improve

De-escalation Options

Dicloxacillin 500mg PO Q6h

OR

OR

Alternative (including for patients with severe penicillin allergy i.e. anaphylaxis, angioedema, hives, etc.)

Duration

The total duration of therapy for uncomplicated cellulitis is 7 days

Longer duration may be required in complicated cases (deep abscesses or necrotizing infections) and depending on clinical response