Necrotizing Fasciitis

Consult

Please send deep tissue cultures at the time of surgical debridement

Empiric Antimicrobial Therapy

  • Loading dose of 20 mg/kg once is recommended

  • Q8h dosing is preferred in young adults

PLUS

Limit duration to 5 days for suppression of toxin production

PLUS EITHER

OR

OR

Alternative (including for patients with severe penicillin allergy i.e. anaphylaxis, angioedema, hives, etc.)

De-escalation

If due to beta-hemolytic streptococci (grp A, B, etc.)

OR

If due to beta-hemolytic streptococci (grp A, B, etc.)

PLUS

Limit duration to 5 days for suppression of toxin production