Prophylaxis/treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Skin and soft tissue infections
Pregnancy: Amoxicillin/clavulanic acid may be associated with NEC in the newborn if given near delivery in the setting of PPROM.
Breastfeeding: Compatible.
For prolonged therapy monitor liver enzymes, CBC
Hepatotoxicity due to calvulanate- usually mild, liver failure is rare
Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash
Increased risk of rash with allopurinol
Consideration of transition from Piperacillin-Tazobactam to IV Amoxicillin-Clavulanate in select cases will be undertaken in conjunction with Antimicrobial Stewardship
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Average serum half life: 1.0
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic