Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Spectrum Of Activity

Dosing

875mg PO BID or 500mg PO TID of the amoxicillin component

<10 eGFR10 - 30 eGFR30+ eGFR250-500mg amoxicillin component daily - BID (do not use 875mg tablet, if eGFR <30)250-500mg amoxicillin component po BID (do not use 875mg tablet if eGFR <30)875mg PO BID or 500mg PO TID of the amoxicillin component

250-500mg PO amoxicillin component BID

General Information

For prolonged therapy monitor liver enzymes, CBC

Hepatotoxicity due to calvulanate- usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash

Increased risk of rash with allopurinol

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Prophylaxis/treatment of bite wounds

Polymicrobial infections of the respiratory tract or abdomen

Skin and soft tissue infections