In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.
If worsening renal function, actual GFR is likely lower than calculated.
If improving renal function, actual GFR is likely higher than calculated eGFR.
Note
Adjusted dose refers to the amoxicillin component
PO
250-500mg PO BID
IV
1000mg followed by 500mg every 12 hours
1000mg followed by 500mg every 12 hours