Renal function, K, Mg, HCO3, liver enzymes, CBC.
Frequency depends on course, but daily reasonable during initiation
Infusion related symptoms: fever/rigors/N/V/headache (see additional information)
Electrolyte abnormalities - hypoK and hypoMg, loss of bicarb (see additional information re: electrolyte infusions)
Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy
Digoxin - increased digoxin toxicity with hypokalemia
Infectious Disease to approve use.
Careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN
Antimicrobial class: Antifungal - polyene
Pregnancy category: B
Average serum half life: 24.0
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
Induction therapy for dimorphic fungii (cocci, blasto, histo)