Amphotericin B deoxycholate

C. diff Risk

Low

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

0.3-1.5mg/kg IV daily, infused over several hours.

Must be approved by Infectious Disease.

0.3-1.5mg/kg IV daily, infused over several hours.

0.4-1mg/kg IV q24h, infused over several hours.
Discuss with pharmacy dosing as well as premedication, see additional information

General Information

Renal function, K, Mg, HCO3, liver enzymes, CBC.

Frequency depends on course, but daily reasonable during initiation

Infusion related symptoms: fever/rigors/N/V/headache (see additional information)

Electrolyte abnormalities - hypoK and hypoMg, loss of bicarb (see additional information re: electrolyte infusions)

Nephrotoxicity ++

Anemia
Phlebitis
Arachnoiditis
Urinary retention
Paresthesias

Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy

Digoxin - increased digoxin toxicity with hypokalemia

Infectious Disease to approve use.

Careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN

Antimicrobial class: Antifungal - polyene

Pregnancy category: B

Average serum half life: 24.0

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity

Induction therapy for dimorphic fungii (cocci, blasto, histo)