C. diff Risk


Oral Bioavailability



1-2g IV q4-6h

Meningitis or Endocarditis: 2g IV q4h

0 - 25 eGFR25 - 50 eGFR50+ eGFR1-2g IV q8-12h 1-2g IV q6-8h1-2g IV q4-6h

1-2g IV q12h, dose after HD on dialysis days (higher doses required for severe infections)

Load 2g then 1-2g IV q8h

General Information

Allergy and rash as for all beta-lactams
EBV related rash (not allergy)
Rare: cytopenias, positive Coombs

Increased risk of rash with allopurinol

Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria