Aztreonam - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 10 eGFR

2g IV q24h

10 - 50 eGFR

3-4g IV daily divided q8-12h

50+ eGFR

2g IV q8h

0.5-2g IV load then 500mg IV q12h

2g IV load then 1g IV q6h