Cefazolin

AWaRe
C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

2 g IV q8h

0 - 30 30 - 50 50+ 2g IV q12-24h2g IV q12h2g IV q8h

1-2g IV QHD given post-HD on dialysis days

2g IV q12h

General Information

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.