2 g IV q8h
0 - 30 30 - 50 50+ 2g IV q12-24h2g IV q12h2g IV q8h
1-2g IV QHD given post-HD on dialysis days
2g IV q12h
Allergy (immediate or delayed).
Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.
Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2.0
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis
Susceptible Staphylococcal, Streptococcal and Gram negative infections.