Cefotaxime

C. diff Risk

High

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

1-2g IV q6-8h

0 - 30 eGFR30 - 50 eGFR50+ eGFR1-2g IV q12-24h1-2g IV q8-12h1-2g IV q6-8h

1-2g IV q24h, dosed after HD on dialysis days

2g IV q12h

General Information

Rash, localized phlebitis at injection site, allergy.

Positive Coombs test, neutropenia, abnormalities in liver enzymes.

Diarrhea and CDI.

Prefer ceftriaxone for CNS infection in renal failure.

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Empiric therapy for bacterial meningitis, pneumonia (in combination with a macrolide), intra-abdominal infection including SBP, musculoskeletal i.e. septic arthritis, and urinary tract infection.