1-2g IV q6-8h
0 - 30 eGFR30 - 50 eGFR50+ eGFR1-2g IV q12-24h1-2g IV q8-12h1-2g IV q6-8h
1-2g IV q24h, dosed after HD on dialysis days
2g IV q12h
Rash, localized phlebitis at injection site, allergy.
Positive Coombs test, neutropenia, abnormalities in liver enzymes.
Diarrhea and CDI.
Prefer ceftriaxone for CNS infection in renal failure.
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 1.5
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Empiric therapy for bacterial meningitis, pneumonia (in combination with a macrolide), intra-abdominal infection including SBP, musculoskeletal i.e. septic arthritis, and urinary tract infection.