1-2g IV q8h
0 - 10 eGFR10 - 30 eGFR30 - 50 eGFR50+ eGFR2g IV q48-72h2g IV q24h2g IV q12h2g IV q8h
2g IV qHD give dose after dialysis
2g IV q8h
Allergy/rash (immediate or delayed).
Can cause positive Coombs, cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2.0
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins