C. diff Risk


Oral Bioavailability



1-2g IV q8h

0 - 10 eGFR10 - 30 eGFR30 - 50 eGFR50+ eGFR2g IV q48-72h2g IV q24h2g IV q12h2g IV q8h

2g IV qHD give dose after dialysis

2g IV q8h

General Information

Allergy/rash (immediate or delayed).

Can cause positive Coombs, cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins