C. diff Risk


Oral Bioavailability


Approximate Cost

Spectrum Of Activity


500mg PO BID

General Information

Common Usage

CAP, Pertussis, URTI, H. pylori, and mycobacterial infections

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • Neutropenia

  •  GI upset

  •  Prolongation of QTc interval

  •  Drug interactions

Major Interactions

  •  CYP450 interactions ++

  •  Other QTc prolonging agents

  •  Recommend review of pt medications due to high frequency of significant interactions

  •  Statins - increased rhabdo

  •  CCBs - hypotension, AKI

  • Colchicine - increased bone marrow toxicity

  •  Increased tacrolimus levels

  •  Increased phenytoin levels

  • Increased INR with warfarin

Additional Information

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing

May exacerbate muscle weakness in persons with myasthenia gravis. Avoid Use.


Antimicrobial class: Macrolide

Pregnancy category: C

Average serum half life: 5.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor