Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

3.375 IV q6h

Severe Pseudomonas infections: 4.5g IV q6h

0 - 30 eGFR30 - 50 eGFR50+ eGFR2.25g IV q6h3.375g IV q6h3.375-4.5g IV q6h

2.25g IV q8h

3.375g IV q6h

General Information

Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes

Incr. levels of methotrexate

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia