Tigecycline

Restricted
C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

100mg IV load on day 1 then 50mg IV q12h

Severe impairment - Child Pugh C - 100mg load on day 1 then 25mg IV daily

General Information

Avoid or use with caution in patients with tetracycline reactions

GI side effects very prominent with significant nausea and vomiting

Tetracycline related adverse events: photosensitivity, acute pancreatitis

Rash, abnormal liver enzymes

Oral contraceptives less effective

Requires Infectious Disease consultation

Documented safety concerns in bacteremia

An increase in all-cause mortality has been observed in a meta-analysis of phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning