Aerobic gram negative rod
Humans are the reservoir - fecal-oral transmission.
Increased prevalence in developing countries.
Highest prevalence South Asia
Fever in Returning Traveler, Enteric fever, FUO, Bacteremia, Intra-abdominal abscess, Meningitis, Endovascular infection including endocarditis and infected atherosclerotic plaque/aneurysm - "sticky" organism
Very high rates of FQ resistance in Indian Subcontinent.
Vaccination only prevents ~75% of disease.
Chronic carriage associated with gallbladder disease - think "Typhoid Mary"
Notify Medical Officer of Health (Reportable)