Restricted
Targeted therapy of resistant gram positive infections with:
MRSA or other Gram-positive infections in patients who cannot receive 1st line agents
Vancomycin Resistant Enterococcus
Note:
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
Antimicrobial class: Cyclic Lipopeptide.
Pregnancy category: B
Average serum half life: 9 hours
Urine penetration: Therapeutic
Lung penetration: Poor
CSF penetration: Poor
Can obtain sensitivities on request
Higher doses used for endovascular infection.
Recommend Infectious Disease Consult.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.