In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Dosing Information
If usual dose is 500 mg IV/PO q24h
500 mg once then 250 mg IV/PO q24h
500 mg IV/PO once then 250 mg IV/PO q48h
500 mg IV/PO once then 250 mg IV/PO q48h
If usual dose is 750 mg IV/PO q24h
750 mg IV/PO q48h
750 mg IV/PO once then 500 mg IV/PO q48h
750 mg IV/PO once then 500 mg IV/PO q48h