Surgical Prophylaxis

Note

These guidelines provide general recommendations for appropriate prophylactic antibiotic use for common surgical procedures; the list of surgical procedures is not all inclusive

More Information

  1. Bratzler, D., Dellinger, E. P., Olsen, K., Perl, T., Auwaerter, P., Bolon, M., et al. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. American Journal of Health System Pharmacy, 70, 195-28.
  2. Capital Health Halifax, Antimicrobial Handbook, Surgical Prophylaxis. Capital Health, 2012;(93-100).
  3. Blondel-Hill, Fryters. Surgical Prophylaxis in Adult Patients. Bugs and Drugs App. Accessed May 16, 2018.
  4. Lagace-Weins P, Rubinstein E. Adverse reactions to beta-lactam antimicrobials. Expert Opin Drug Saf 2012; 11:381-399.
  5. Van Eyk, N, van Schalkwyk J, et al. Antibiotic Prophylaxis in Gynaecologic Procedures. J Obstet Gynaecol Can 2012;34(4):382–391.
  6. Berrios-Torres SI, Umsheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guidelines for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017;152(8):784-91.
  7. Sunnybrook Antimicrobial Handbook 2013, Surgical Antibiotic Prophylaxis. Sunnybrook Hospital, 2013;105-121.
  8. O’Neal PN, Itani KMF. Antimicrobial Formualtion and Delivery in the Prevention of Surgical Site Infection. Surgical Infections 2016;17(3):275-85.
  9. The Sanford Guide to Antimicrobial Therapy 2015, Table 15B – Antibiotic Prophylaxis to Prevent Surgical Infections in Adults.
  10. 2016 Sick Kids Drug Handbook and Formulary, Surgical Prophylaxis for Neonates and Paediatric Patients. The Hospital for Sick Children, 2016:360-76.
  11. Red Book: 2015 Report of the Committee on Infectious Diseases, Antimicrobial Prophylaxis in Pediatric Surgical Patients. American Academy of Pediatrics. Accessed online 2017/10/11.
  12. The Medical Letter. Antimicrobial Prophylaxis for Surgery. The Medical Letter on Drugs and Therapeutics 2016;58(1495):63-8.
  13. Tita TN, Szychowski JM, Boggess K, et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. NEJM 375;13:1231-41
  14. Antibiotic Prophylaxis for Gynecological Proceddures. Clinical Management Guidelines for Obstetrician-Gynecologist. ACOG Practice Bulletin Nubmer 104, May 2009, Reaffirmed 2014.
  15. Eyk NV and Schalkwyk JV. Antibiotic Prophylaxis in Gynaecologic Procedures. J Obstet Gynaecol Can 2012;34(4):382-391
  16. Wolf JS, Bennett CJ, Dmochowski RR, et al. Urological Surgery Antimicrobial Prophylaxis – Best Practice Statement from the American Urological Association. Published 2008, Reviewed and Validity Confirmed 2011; amended 2012. (Accessed online January 4, 2018)
  17. Blumenthal KG, Ryan EE, Li Y, et al. The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. Clinical Infectious Diseases 2018;66(3):329-336
  18. Hoff WS, Bonadies JA, Cachecho R and Dorlac WC. East Practice Management Guidelines Work Group: Update to Practice Management Guidelines for Prophylactic Antibiotic Use in Open Fractures. J Trauma. 2011 Mar;70(3):751-4.
  19. Schmitt SK. Treatment and Prevention of Osteomyelitis Following Trauma in Adults. In: UpToDate, Sexton DJ (Ed), UpToDate, Waltham, MA. (Accessed on May 16, 2018)
  20. Gosselin RA, Roberts I and Gilepsie WJ. Antibiotics for Preventing Infection in Open Limb Fractures. Cochrane Database Syst Rev. 2004;(1):CD003764.