Antimicrobial prophylaxis is generally unnecessary for “clean” surgical procedures
For the majority of surgical procedures in which antimicrobial prophylaxis is indicated, a single dose of ceFAZolin 2 g IV given within the 60 minutes before the first surgical incision is appropriate
Severe non-IgE mediated hypersensitivity reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, immune hepatitis, hemolytic anemia, serum sickness, interstitial nephritis, small vessel vasculitis)- warrant the avoidance of all beta-lactams
Idiopathic reactions are not clearly immune-mediated (non-pruritic morbilliform rash) and are not a contraindication to taking a different beta-lactam such as ceFAZolin
For more information on assessing beta-lactam allergies, please see the:
Consider pre-procedural MRSA decolonization
Consider consult to infectious diseases/medical microbiology for recommendations