For antimicrobials with short half-lives, intra-operative dosing is recommended for patients with normal renal function if:
Prophylactic Antibiotic | Half life (hours) | Re-dosing interval* |
---|---|---|
ceFAZolin | 1.2-2.2 | Q4h |
clindamycin | 2-4 | Q6h |
aminoglycoside | 2-3 | N/A** |
metroNIDAZOLE | 6-8 | N/A** |
vancomycin | 4-8 | N/A** |
* Recommended re-dosing interval from time of administration of the pre-op dose
** Not applicable (N/A) based on typical case length; for unusually long procedures, redosing may be needed except for aminoglycoside dosed at 5 mg/kg
Antimicrobial prophylaxis for patients with renal or hepatic dysfunction often does not need to be modified when given as a single dose pre-operatively
Ideal body weight (males)
Ideal body weight (females)
Dosing body weight
Vancomycin 15 mg/kg based on patient’s ABW and rounded to the nearest 250 mg
Note: This guideline is intended for adults only. Pediatric dosing provided in table below: Please note:
Antibiotic | Recommended Dose |
---|---|
ampicillin | 50 mg/kg |
ceFAZolin | 30 mg/kg |
cefTRIAXone | 50-70 mg/kg |
ciprofloxacin | 10 mg/kg |
clindamycin | 10 mg/kg |
aminoglycoside | 2.5 mg/kg |
metroNIDAZOLE | 15 mg/kg |
piperacillin-tazobactam | see below* |
vancomycin | 15 mg/kg |
*Infants 2-9 months: 80 mg/kg of the piperacillin component. *Children greater than 9 months and less than or equal to 40kg: 100 mg/kg of the piperacillin component