Immediate, IgE mediated allergies include, but are not limited to, anaphylaxis, urticaria, angioedema, hypotension, bronchospasm, stridor, and pruritic rash
Refer to the NB-ASC Beta-Lactam Allergy guidelines to determine which beta-lactams share similar side chains (see link below)
Severe delayed hypersensitivity reactions to beta-lactams are caused by mechanisms that are not well known and require that subsequent use of beta-lactams be avoided.
Severe delayed hypersensitivity reactions can include interstitial nephritis, immune hepatitis, hemolytic anemia, serum sickness, severe cutaneous reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms (DRESS).