Glomerular filtration rate can be increased by up to 50% in pregnant and post-partum patients, resulting in a shorter half-life compared to nonpregnant women
Volume of distribution is increased in pregnancy, while the post-partum period is associated with increased mobilization of fluid followed by diuresis as the body eliminates the increased fluid volume of pregnancy
Data limited on extended interval dosing of AG in pregnancy; use with caution
More data on extended interval dosing of AG in post-partum