Guidelines
Pregnancy and Post-Partum

Pregnancy and Post-Partum

Note

Glomerular filtration rate can be increased by up to 50% in pregnant and post-partum patients, resulting in a shorter half-life compared to nonpregnant women

Volume of distribution is increased in pregnancy, while the post-partum period is associated with increased mobilization of fluid followed by diuresis as the body eliminates the increased fluid volume of pregnancy

Gentamicin/Tobramycin Extended Interval Dosing

Data limited on extended interval dosing of AG in pregnancy; use with caution

More data on extended interval dosing of AG in post-partum

Gentamicin/Tobramycin Conventional Dosing