Recommended Dose: 25-30 mg/kg IV
If loading dose not used then proceed with administration of a maintenance dose at recommended dosing interval
15-20 mg/kg IV
Interval depends on patient’s renal function and targeted serum vancomycin concentration
Creatinine Clearance (mL/min) | Dosing Interval |
---|---|
Greater than 80 | q8-12h |
40 to 80 | q24h |
20 to 39 | q36h |
10 to 19 | q48h |
Less than 10 | Consider a loading dose, then adjust maintenance dose based on serial serum drug levels to target trough |
CrCl = [(140-age) x weight (in kg)] / SCr (in mcmol/L)
Weight
IBW
Adjusted body weight
CrCl = [(140-age) x weight (in kg) x 1.2] / SCr (in mcmol/L)
Weight
IBW
Adjusted body weight