Vancomycin Dosing and Monitoring

General Information

Additional Information

  1. Rybak MJ. The pharmacokinetic and pharmacodynamics properties of vancomycin. CID 2006;42 (suppl1):S35-S39.
  2. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health-Syst Pharm 2009;66:82-98.
  3. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-resistant Staphylococcus Aureus infection in adults and children. CID 2011;52:1-38.
  4. Matsumoto K, Takesue Y, Ohmagari N, Mochizuki T, Mikamo H, et al. Practice guidelines for therapeutic drug monitoring of vancomycin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. J Infect Chemother 2013;19:365-380.
  5. Kulla R, Leonard SN, Davis SL, Delgado G, Pogue JM et al. Validation of the effectiveness of a vancomycin nomogram in achieving target trough concentrations of 15-20 mg/L suggested by the vancomycin consensus guidelines. Pharmacotherapy 2011;31(5):441-448.
  6. Thalakada R, Legal M, Lau TTY, Luey T, Batterink J et al. Development and validation of a novel vancomycin dosing nomogram for high-target trough levels at 2 Canadian teaching hospitals. Can J Hosp Pharm 2012;65(3):180-187.
  7. De Lemos J, Lau T, Legal M, Betts T, Collins M, et al. Vancomycin Therapeutic Drug Monitoring, Vancouver Coastal Health & Providence Health Care Regional Guideline. September 2011.
  8. Alberta Health Services. Vancomycin Monitoring and Dosing Guideline. 2011.
  9. IWK Guidelines for Monitoring Vancomycin. 2014.
  10. IWK Formulary and Dosing Handbook. Vancomycin monograph. 2015.
  11. Van Hal SJ, Paterson DL, Lodise TP. Systematic review and meta-analysis of vancomycin-induced nephrotoxicity associated with dosing schedules that maintain troughs between 15 and 20 milligrams per liter. Antimicrob Agents and Chemother 2013;57(2):734-744.
  12. Reardon J, Lau TTY, Ensom MHH. Vancomycin loading doses: a systematic review. Annals of Pharmacotherapy 2015;49(5):557-565.
  13. Blond-Hill E, Fryters S. Bugs & Drugs, An Antimicrobial/Infectious Diseases Reference. 2012. Alberta Health Services
  14. Zelenitsky SA et al. Initial vancomycin dosing protocol to achieve therapeutic serum concentrations in patients undergoing hemodialysis. CID 2012:55:527-533.
  15. Vancomycin Therapeutic Drug Monitoring. Vancouver Coastal Health & Providence Health Care Regional Guidelines. September 27, 2011
  16. Gaps in Transition: Management of Intravenous Vancomycin Therapy in the Home and Community Settings. ISMP Canada Safety Bulletin. Volume 16; issue 4; June 28, 2016

Guideline content derived from:

  • NB Provincial Health Authorities Anti-Infective Stewardship Committee. Vancomycin Dosing and Monitoring Guidelines. 10-2020